Wednesday, August 5, 2026 Login
Breaking
Bing Webmaster Tools To Gain Page & Query Level Filtering Shares to buy or sell: Chandan Taparia of Motilal Oswal recommends three stocks to buy today – 4 August 2026 Will Mohammad Amir Play IPL? He Finally Responds Precautionary Measures Limit the Spread of Foot-and-Mouth Disease in the Southern Region Abhijeet Dipke student protests: Follow Gandhi, not Bangladesh or Nepal
Health

Losing sleep over glia: new mechanisms for Alzheimer-related sleep disruption

  • Ferini-Strambi, L. et al. Role of sleep in neurodegeneration: the consensus report of the 5th Think Tank World Sleep Forum. Neurol. Sci. 45, 749–767 (2024).

    Article 
    PubMed 

    Google Scholar
     

  • McConnell, B. V., Deng, Y. & Lucey, B. P. Sleep and neurodegeneration: examining potential physiological mechanisms. Curr. Sleep Med. Rep. 11, 1 (2025).

    Article 

    Google Scholar
     

  • Pulver, R. L. et al. Mapping sleep’s oscillatory events as a biomarker of Alzheimer’s disease. Alzheimers Dement. 20, 301–315 (2024).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Slutsky, I. Linking activity dyshomeostasis and sleep disturbances in Alzheimer disease. Nat. Rev. Neurosci. 25, 272–284 (2024).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Constantino, N. J. et al. Early microglial response to amyloid plaques drives sleep loss in Alzheimer’s disease. Alzheimers Dement. 22, e71579 (2026).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Ma, C. et al. Microglia regulate sleep through calcium-dependent modulation of norepinephrine transmission. Nat. Neurosci. 27, 249–258 (2024).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Porter, T. et al. Evidence for direct and sleep-moderated relationships between aquaporin-4 genetic variants and Alzheimer’s disease phenotypes. Alzheimers Dement. 22, e71516 (2026).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Jansen, W. J. et al. Prevalence estimates of amyloid abnormality across the Alzheimer disease clinical spectrum. JAMA Neurol. 79, 228–243 (2022).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Mormino, E. C. et al. Synergistic effect of β-amyloid and neurodegeneration on cognitive decline in clinically normal individuals. JAMA Neurol. 71, 1379–1385 (2014).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Zhao, Q. et al. Sleep restoration by optogenetic targeting of GABAergic neurons reprograms microglia and ameliorates pathological phenotypes in an Alzheimer’s disease model. Mol. Neurodegener. 18, 93 (2023).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Source link

    Related Stories

    Leave a Comment

    Your email address will not be published. Required fields are marked *