This Assortment helps and amplifies analysis associated to SDG 3 – Good health & well being.
In vitro techniques have turn into indispensable instruments for modelling human biology, enabling mechanistic investigation of growth, physiology, and illness in experimentally tractable settings. Advances in stem cell biology, tissue engineering, biomaterials, and microfluidics have pushed the event of more and more refined platforms, starting from 2D cell cultures and 3D spheroids to organoids, organ-on-a-chip applied sciences, and multi-organ microphysiological techniques.
These fashions can seize key options of tissue structure, mobile interactions, and physiological operate whereas providing alternatives to enhance drug discovery, toxicity testing, and translational analysis. As human cell-based fashions proceed to evolve, they’re more and more getting used as new method methodologies (NAMs) to enrich or substitute conventional animal fashions and to supply insights into human-specific biology. The Editors at Communications Biology now invite submissions that advance the event, validation, and utility of in vitro techniques throughout organic and biomedical analysis.
Subjects of curiosity embody, however should not restricted to:
- 2D and 3D human cell tradition techniques
- Spheroids, organoids, and different self-organising tissue fashions
- Organ-on-a-chip and organ-chip applied sciences
- Microfluidic platforms and microphysiological techniques (MPS)
- Multi-organ and human-on-a-chip fashions
- Tissue-specific techniques, together with lung-, liver-, heart-, and gut-on-a-chip fashions
- Functions in drug discovery, drug growth, and toxicology
- Validation, benchmarking, and standardisation of NAMs
- Integration of superior imaging, omics, and computational strategies with in vitro techniques
