WHO emergency steerage on the usage of licensed Ebola vaccine throughout Bundibugyo virus illness outbreaks, 31 August 2026
Following the Extraordinary Assembly of the Strategic Advisory Group of Consultants (SAGE) on Immunization held on 19 August 2026, at this time WHO has printed new emergency steerage on the usage of licensed Ebola vaccine throughout Bundibugyo virus illness outbreaks.
The up to date WHO emergency steerage outlines six suggestions:
- Ervebo® ought to solely be used for Bundibugyo virus (BVDV) throughout the context of a analysis protocol at the moment.
- Ring vaccination Randomized Managed Trial (RCT) is taken into account probably the most strong and dependable method to find out the efficacy of Ervebo® towards Bundibugyo virus (BDBV).
- The place broader use could also be pursued earlier than the efficacy trial outcomes, a complete risk-mitigation plan needs to be applied to handle the dangers
- Continues to suggest preventive use of Ervebo® amongst HCW/FLW in Ebola virus (EBOV)-priority areas of nations with a historical past of Ebola virus illness (EVD) outbreaks.
- In areas affected by the present BDBV outbreak, Ervebo® ought to solely be used for the outbreak response inside a analysis protocol, akin to a hoop RCT or well-designed observational VE examine to offer further details about potential efficiency of Ervebo® towards BVD.
- Exceptionally, if such analysis shouldn’t be possible, off-label use could also be thought-about, offered strong vaccination information allow dependable identification of vaccine recipients and linkage to subsequent BDBV exposures and well being outcomes.
- Speed up the event and rigorous analysis of BDBV-specific vaccines and post-exposure prophylaxis merchandise.
- Encourage clear coordination between companions for well timed assist to the DRC and every other nation contemplating the usage of Ervebo® inside a analysis protocol within the present BDBV outbreak. Ideally, grasp protocol(s) for the ring RCT and high-quality observational research needs to be developed and shared
Learn the up to date steerage right here.
