Increased dietary consumption of antioxidants is related to a decrease prevalence of cervical cancer amongst US girls, in keeping with analysis revealed within the Worldwide Journal of Gynecology & Obstetrics.
“Diets wealthy in fruits, greens, and entire grains have been related to a decrease threat of most cancers, doubtlessly as a result of these meals present antioxidant vitamins, together with nutritional vitamins A, C, D, and E, carotenoids, zinc, and selenium,” research researchers defined. “Latest evaluate proof means that protecting dietary elements might affect HPV an infection and [cervical cancer] growth by modulating immune responses, oxidative stress, and irritation.”
On this retrospective, cross-sectional research, the researchers assessed the affiliation between the Composite Dietary Antioxidant Index (CDAI), a validated composite rating reflecting the dietary consumption of antioxidants, and the prevalence of cervical most cancers amongst US girls, utilizing 2003-2018 knowledge from the Nationwide Well being and Diet Examination Survey.
Of 1044 girls included within the research, 174 had a historical past of cervical most cancers and 870 served as matched controls. Members with a historical past of cervical most cancers have been extra seemingly than the management people to smoke, reside alone, and have a physique mass index (BMI) higher than 30 kg/m2. Nonetheless, there have been no vital variations between the teams in training stage, hypertension, diabetes, or ingesting standing.
When assessed as a steady variable, increased CDAI was constantly related to a decrease prevalence of cervical most cancers throughout unadjusted, partially adjusted, and absolutely adjusted weighted logistic regression fashions. Within the absolutely adjusted mannequin, every unit enhance in CDAI was linked to an 11.4% decrease prevalence of cervical most cancers (odds ratio [OR], 0.886; 95% CI, 0.819-0.958; P =.003).
Within the absolutely adjusted mannequin, members within the highest tertile of CDAI had a 55.8% decrease prevalence of cervical most cancers in contrast with these within the lowest tertile group (OR, 0.442; 95% CI, 0.245-0.797; P =.007).
General, restricted cubic spline regression evaluation confirmed that there was a big inverse affiliation between CDAI and prevalence of cervical most cancers (P =.012).
In subgroup analyses, the researchers discovered a constant relationship between CDAI and cervical most cancers, with no statistically vital variations by age, race and ethnicity, marital standing, training stage, poverty-income ratio, smoking standing, ingesting standing, BMI, hypertension, and diabetes.
“Though earlier research have urged that dietary antioxidant consumption, dietary high quality, and oxidative stress might differ amongst socioeconomic and behavioral teams, our research didn’t present adequate proof that these traits modified the affiliation between CDAI and [cervical cancer],” the researchers famous.
“These findings counsel that dietary antioxidant consumption might play a possible function within the prevention of [cervical cancer],” the researchers concluded. “Nonetheless, additional potential research are wanted to substantiate this affiliation and make clear the underlying mechanisms.”
Disclosures: This analysis was supported by the Nationwide Key Medical Specialty Building Mission. The research authors reported having no conflicts of curiosity. Please see the unique reference for full disclosures.
