Assortment will concentrate on how structural group and biophysical mechanisms govern most cancers cell progress, proliferation, survival, and adaptation. Led by editors at Communications Biology, Nature Communications, and Scientific Studies, the Assortment goals to carry collectively research spanning molecular to mobile scales, together with structure-guided investigations of DNA, RNA, proteins, and macromolecular assemblies concerned in most cancers growth and development. We’re notably excited about analysis that uncovers mechanistic hyperlinks between molecular construction, dynamics, interactions, and most cancers cell behaviour.
The Assortment welcomes research that leverage structural biology and quantitative biophysical approaches to disclose basic ideas underlying cancer-associated processes. A key emphasis shall be positioned on experimentally validated mechanistic research that combine biophysical or structural methodologies with most cancers biology. Computational, theoretical, and AI-driven approaches are additionally inspired, notably once they present substantial mechanistic perception, predictive energy, or methodological advances with broad relevance to most cancers analysis. Whereas experimental validation is welcomed the place acceptable, distinctive computational research providing vital conceptual or translational advances can even be thought of.
Submissions using superior structural, biophysical, and quantitative approaches are strongly inspired, together with however not restricted to X-ray crystallography, cryo-electron microscopy and tomography (Cryo-EM/ET), nuclear magnetic resonance (NMR) spectroscopy, mass spectrometry, single-molecule biophysics, molecular dynamics simulations, integrative structural biology, machine learning-based structural modelling, and associated applied sciences. Research that present mechanistic insights into most cancers biology throughout molecular and mobile scales shall be notably welcomed.
The scope consists of:
- Construction-guided investigation of cancer-relevant DNA
- RNA, proteins, and macromolecular complexes
- Biophysical mechanisms governing most cancers cell progress, proliferation, survival, and adaptation
- Molecular interactions, conformational dynamics, and regulatory networks underlying cancer-associated processes
- Computational, theoretical, and AI-enabled approaches that present mechanistic perception into most cancers biology via structural and biophysical evaluation
